Regulatory Holidays and Optimal Network Expansion

Modeling gene regulatory networks: Classical models, optimal perturbation for identification of network

Deep understanding of molecular biology has allowed emergence of new technologies like DNA decryption.  On the other hand, advancements of molecular biology have made manipulation of genetic systems simpler than ever; this promises extraordinary progress in biological, medical and biotechnological applications.  This is not an unrealistic goal since genes which are regulated by gene regulatory ...

Evolutionary expansion of a regulatory network by counter-silencing

Horizontal gene transfer plays a major role in bacterial evolution. Successful acquisition of new genes requires their incorporation into existing regulatory networks. This study compares the regulation of conserved genes in the PhoPQ regulon of Salmonella enterica serovar Typhimurium with that of PhoPQ-regulated horizontally acquired genes, which are silenced by the histone-like protein H-NS. ...

Sunday Holidays

. Sir, Will you please find .1 little space for my proposal 111 your valuable paper and oblige. It is rather curious that the medical department should have no holiday unlike other departments, and it is sometimes a matter which causes great inconvenience to its employs. Some years back the work of the Indian dispensaries was light as most of the people were used to the eastern methods of treat...

Happy Holidays

Holidays in the sun.

If you are reading this editorial in the week of publication, chances are that you do not work in one of the countries bordering the Mediterranean. If you are in Scandinavia, this is probably your first opportunity even to read my editorial from July. Most of Europe now takes a full four or five weeks of vacation, usually corresponding to the calendar month of July in the north or August in the...